Pharmacokinetic, antidepressant, antipsychotic, amphetamine, alpha agonist

When ‘new’ psychotropic medications are released on the market, it can be difficult to discern the differences between the newer agents and their similar predecessors. Since head to head clinical trials are rarely available, it is important to learn what can be gleaned from the package inserts and the Food and Drug Administration (FDA) website. These sources are a wealth of information and were used as the primary resources for the comparative tables that follow.

1.
Effexor (venlafaxine HCl) [package insert]
.
Philadelphia, Pennsylvania
;
Pfizer Inc.
;
2012
2.
Effexor XR (venlafaxine HCl) [package insert]
.
Philadelphia, Pennsylvania
;
Wyeth Pharmaceuticals, Inc.
;
2013
3.
Venlafaxine extended release tablets [package insert]
.
Wilmington, North Carolina
;
Osmotica Pharmaceutical
;
2012
4.
Pristiq (desvenlafaxine succinate) [package insert]
.
Philadelphia, Pennsylvania
;
Pfizer Inc.
;
2013
5.
Khedezla (desvenlafaxine) [package insert]
.
Wilmington, North Carolina
;
Osmotica Pharmaceutical Corp.
;
2013
6.
Desvenlafaxine [package insert]
.
Taluka-Halol, Panchmahal, Gujarat, India
;
Alembic Pharmaceuticals Limited
;
2013
7.
Desvenlafaxine fumarate [package insert]
.
Sellersville, Pennsylvania
;
Teva Pharmaceutical Ind, LTD.
;
2013
8.
Savella (milnacipran) [package insert]
.
St. Louis, Missouri
;
Forest Pharmaceuticals, Inc.
;
2013
9.
Fetzima (levomilnacipran) [package insert]
.
St. Louis, Missouri
;
Forest Pharmaceuticals, Inc.
;
2013
10.
Cymbalta (duloxetine) [package insert]
.
Indianapolis, Indiana
;
Lilly USA, LLC
;
2012
11.
Fda.gov. [Internet]. FDA Approved Drug Products
.
Silver Spring, MD
;
U.S. Food and Drug Administration
.
[cited 2013 Nov 20]. Available from http://www.accessdata.fda.gov/scripts/cder/drugsatfda/index.cfm
.
12.
Pristiq (desvenlafaxine succinate) [package insert]
.
Philadelphia, Pennsylvania
;
Wyeth Pharmaceuticals, Inc.
;
2008
(
for pharmacokinetic data only
)
13.
Target pharmacy $4 list of generic medications [Internet]
.
Minneapolis, MN
:
Target Brands, Inc.
[updated 10/2013; cited 2013 Dec 2]. Available from: http://www.target.com/pharmacy/generics-condition#secC
.
14.
Walmart Retail Prescription Program Drug List. [Internet]
.
Bentonville, AR
;
Walmart
.
[updated 2013 Oct 4; cited 2013 Dec 2]. Available from http://i.walmartimages.com/i/if/hmp/fusion/customer_list.pdf
.
15.
Fluoxetine 60 mg [package insert]
.
Austin, Texas
;
Edgemont Pharmaceuticals, LLC
;
2011
16.
Intuniv (guanfacine) [package insert]
.
Wayne, Pennsylvania
;
Shire US Inc.
;
2013
17.
Guanfacine HCl oral tablets [package insert]
.
Morgantown, West Virginia
:
Mylan Pharmaceuticals Inc.
,
2011
.
18.
Kapvay (guanfacine) [package insert]
.
Florham Park, New Jersey
;
Shionogi Inc.
;
2013
19.
Clonidine HCl [package insert]
.
Morgantown, West Virginia
:
Mylan Pharmaceuticals, Inc
;
2002
.
20.
Adderall XR (mixed amphetamine salts) [package insert]
.
Wayne, Pennsylvania
;
Shire US Inc.
;
2013
21.
Dexedrine Spansule (dextroamphetamine sulfate) [package insert]
.
Horsham, Pennsylvania
;
Amedra Pharmaceuticals LLC
;
2013
22.
Desoxyn (methamphetamine hydrochloride) [package insert]
.
Deerfield, Illinois
;
Ovation Pharmaceuticals, Inc.
;
2013
23.
Vyvanse (lisdexamfetamine) [package insert]
.
Wayne, Pennsylvania
;
Shire US Inc.
;
2013
24.
Biederman
J
,
Boellner
SW
,
Childress
A
,
Lopez
FA
,
Krishnan
S
,
Zhang
Y.
Lisdexamfetamine dimesylate and mixed amphetamine salts extended-release in children with ADHD: a double-blind, placebo-controlled, crossover analog classroom study
.
Biol Psychiatry
.
2007
;
62
(
9
):
970
–
6
.
DOI: 10.1016/j.biopsych.2007.04.015. PubMed PMID: 17631866
.
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Crossref
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PubMed
 
25.
Depakene (valproic acid) [package insert]
.
North Chicago, Illinois
;
AbbVie Inc.
;
2013
26.
Depakote Sprinkle Capsules (divalproex sodium coated particles in capsules) [package insert]
.
North Chicago, Illinois
;
AbbVie Inc.
;
2013
27.
Depakote (divalproex sodium) [package insert]
.
North Chicago, Illinois
;
AbbVie Inc.
;
2013
28.
Depakote ER (divalproex sodium) [package insert]
.
North Chicago, Illinois
;
AbbVie Inc.
;
2013
29.
Stavzor (valproic acid delayed release capsule) [package insert]
.
Miami, Florida
;
Noven Therapeutics, LLC
;
2013
© 2014 College of Psychiatric and Neurologic Pharmacists
2014