Effects of hyperthermia (42.5°C) and γ radiation (30 Gy) on ADP-ribosyl transferase, NAD+, and ATP pools in human mononuclear leukocytes have been investigated. It was found that the γ-ray activation level of the enzyme was not influenced by this hyperthermia for 45 min. Following deprivation of ATP synthesis by 2,4-dinitrophenol, an uncoupler of the oxidative phosphorylation, and omitting glucose from the culture medium, the NAD+ pool was reduced to about 60% of control value. The potentiation of ATP production by exogenously supplied adenosine was reduced after a combined treatment of the cells with hyperthermia and γ radiation. Mitochondrial and endoplasmic changes within the mononuclear leukocytes were also observed. Based on these findings a model for the hyperthermia effect is proposed.
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May 01 1985
Influence of Hyperthermia and γ Radiation on ADP-Ribosyl Transferase, NAD+, and ATP Pools in Human Mononuclear Leukocytes
Radiat Res (1985) 102 (2): 241–253.
Citation
Göran G. Jonsson, Göran Eriksson, Ronald W. Pero; Influence of Hyperthermia and γ Radiation on ADP-Ribosyl Transferase, NAD+, and ATP Pools in Human Mononuclear Leukocytes. Radiat Res 1 May 1985; 102 (2): 241–253. doi: https://doi.org/10.2307/3576471
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