Isothermal (37 ± 0.2°C) exposure of glioma cells (LN71) for 2 h to 27 or 2450 MHz continuous-wave radiofrequency (RF) radiation in vitro modulated the rates of DNA and RNA synthesis 1, 3, and 5 days after exposure. The alterations indicate effects on cell proliferation and were not caused by RF-induced cell heating. The dose response for either frequency of the radiation was biphasic. Exposure to specific absorption rates (SARs) of 50 W/kg or less stimulated incorporation rates of tritiated thymidine (3 H- TdR) and tritiated uridine (<tex-math>${}^{3}{\rm H}\text{-}{\rm UdR}$</tex-math>), whereas higher SARs suppressed DNA and RNA synthesis. Statistically significant time-dependent alterations were detected for up to 5 days postexposure, suggesting a kinetic cellular response to RF radiation and the possibility of cumulative effects on cell proliferation. General mechanisms of effects are discussed.
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January 1990
Research Article|
January 01 1990
Glioma Proliferation Modulated in Vitro by Isothermal Radiofrequency Radiation Exposure
Radiat Res (1990) 121 (1): 38–45.
Citation
Stephen F. Cleary, Li-Ming Liu, Randall E. Merchant; Glioma Proliferation Modulated in Vitro by Isothermal Radiofrequency Radiation Exposure. Radiat Res 1 January 1990; 121 (1): 38–45. doi: https://doi.org/10.2307/3577561
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