A combined in vivo-in vitro model has been utilized to evaluate the influence of cell-cell interactions on expression of radiation-induced transformation in irradiated rat tracheal epithelial cells. Two types of cell interactions are evaluated. One type of interaction appears to involve direct cell-cell contact as occurs within the intact tissue. The other type of communication appears to be mediated via a diffusible factor, most likely transforming growth factor type-β. The data suggest the need to be cautious when extrapolating from transformation data obtained following irradiation of low-density rapidly proliferating cell cultures to the in vivo model.
Interactions between Cell Populations Influence Expression of the Transformed Phenotype in Irradiated Rat Tracheal Epithelial Cells
- Views Icon Views
- Share Icon Share
- Search Site
M. Terzaghi-Howe; Interactions between Cell Populations Influence Expression of the Transformed Phenotype in Irradiated Rat Tracheal Epithelial Cells. Radiat Res 1 March 1990; 121 (3): 242–247. doi: https://doi.org/10.2307/3577772
Download citation file: