The repair of radiation-induced DNA double-strand breaks (DSBs) is analyzed kinetically. It is assumed that a fraction of the damaged sites in the DNA duplex are irreparable. The kinetic model takes the effect of radiation dose into account. The analysis of the available experimental data reveals that, although the number of irreparable DSBs is a quadratic function of radiation dose, the normalized number of irreparable DSBs correlates linearly with this variable.
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Research Article| June 01 1990
A Kinetic Analysis of the Repair of Radiation-Induced DNA Double-Strand Breaks
Radiat Res (1990) 122 (3): 333–336.
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Shiojenn Tseng, Jyh-Ping Hsu; A Kinetic Analysis of the Repair of Radiation-Induced DNA Double-Strand Breaks. Radiat Res 1 June 1990; 122 (3): 333–336. doi: https://doi.org/10.2307/3577764
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