The radioprotector WR-33278, the disulfide of WR-1065 (N-(2-mercaptoethyl)-1,3-diaminopropane), is shown to stimulate eukaryotic topoisomerase I unwinding of negatively supercoiled DNA. This observation suggests the possibility that some protection may be conferred to DNA either by a decrease in its supercoiled state or by altering directly other enzymatic processes. This is the first report of a radioprotective compound stimulating an enzyme involved in DNA structure and synthesis.
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Research Article| October 01 1990
Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278
Eric A. Holwitt ;
Radiat Res (1990) 124 (1): 107–109.
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Eric A. Holwitt, Erik Koda, C. E. Swenberg; Enhancement of Topoisomerase I-Mediated Unwinding of Supercoiled DNA by the Radioprotector WR-33278. Radiat Res 1 October 1990; 124 (1): 107–109. doi: https://doi.org/10.2307/3577703
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