The response of the epidermis was compared in two strains of pig, the English Large White and the Göttinger Miniature, after irradiation with90 Sr β rays. The effects of two types of anesthesia were also tested in pigs of each strain, a volatile gas mixture of ∼70% oxygen, ∼30% nitrous oxide, and 2% halothane, and an intravenously administered narcotic azaperon/etimodat with the animals breathing air. Strain- and anesthetic-related changes were compared on the basis of dose-effect curves for the incidence of moist desquamation from which ED50 values (±SE) were determined, i.e., the dose required to produce this effect in 50% of the fields irradiated. For English Large White pigs anesthetized with the volatile gas mixture, an ED50 of 27.32 ± 0.52 Gy was obtained for moist desquamation. Irradiation with the azaperon/etomidat anesthesia in this strain of pig produced a significantly higher ED50 of 33.36 ± 0.76 Gy (P < 0.001). This appeared to be related to the fact that the animals were breathing air, i.e., a lower oxygen concentration (∼21%), at the time of irradiation. For the Göttinger Miniature pig the ED50 values for moist desquamation were 38.93 ± 3.12 Gy and 43.36 ± 1.34 Gy while using the gaseous anesthetic mixture and the azaperon/etomidat anesthesia with the animals breathing air, respectively. These ED50 values are 10-11 Gy higher than those obtained for the English Large White pig under identical conditions of anesthesia, which resulted in a strain difference ratio of ∼1.35. Radiation under the volatile gas mixture anesthesia resulted in a uniform irradiation response over the skin of the flank in both strains of pig. Radiation under azaperon/etomidat anesthesia resulted in a nonuniform skin response over the flank. The ED50 for moist desquamation was significantly higher in dorsal sites on the flank compared with the ventral area of English Large White pigs; a similar trend was seen in Göttinger Miniature pigs. This difference in the radiosensitivity over the flank skin while the animals are under azaperon/etomidat anesthesia at the time of irradiation was associated with the animals breathing air and is in agreement with findings published previously for animals under halothane anesthesia and breathing air.
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Research Article| December 01 1990
A Comparison of the Radiation Response of the Epidermis in Two Strains of Pig
G. J. M. J. van den Aardweg ;
Radiat Res (1990) 124 (3): 283–287.
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G. J. M. J. van den Aardweg, M. Arnold, J. W. Hopewell; A Comparison of the Radiation Response of the Epidermis in Two Strains of Pig. Radiat Res 1 December 1990; 124 (3): 283–287. doi: https://doi.org/10.2307/3577840
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