Interleukin 1 has been shown to provide protection against the toxic effects of cyclophosphamide given in combination with localized irradiation of the lung. A single dose of 15 μg/kg interleukin 1 was given 24 h before cyclophosphamide (25-125 mg/kg) which was followed 1 day later by five daily exposures of 4.5 or 5.0 Gy, localized to the lung. Interleukin 1 significantly reduced early measurements of breathing rate for mice treated with high cyclophosphamide doses and irradiation, and at cyclophosphamide doses above 50 mg/kg, there was a significant reduction in the lethality from the combined treatment. At lower levels of cyclophosphamide, however, there seemed to be no effect.
Protection by Interleukin 1 against Lung Toxicity Caused by Cyclophosphamide and Irradiation
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Mary J. Dorie, Gabriella Bedarida, Robert F. Kallman; Protection by Interleukin 1 against Lung Toxicity Caused by Cyclophosphamide and Irradiation. Radiat Res 1 December 1991; 128 (3): 316–319. doi: https://doi.org/10.2307/3578055
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