Excision-deficient haploid yeast cells (Saccharomyces cerevisiae) were exposed to 254-nm UV radiation and protein synthesis inhibition was measured for a large number of different proteins resolved by two-dimensional gel electrophoresis. The derived UV-radiation sensitivities exhibited an overall increase with protein molar mass. Quantitatively, this behavior is compatible with a well known mechanism of transcription inactivation-termination of RNA chains at UV-radiation-induced pyrimidine dimers-if the respective target sizes are inferred from protein molar mass. The observed deviations from the predicted response suggest that (i) UV-radiation damage may also interfere with recognition/binding of RNA polymerase to regulatory sequences and (ii) the frequency of photolesions for a specific protein encoding gene may differ markedly from the mean induction rate for the total yeast genome.
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Research Article| February 01 1992
Protein Synthesis in Irradiated Cells: I. Ultraviolet Radiation
Radiat Res (1992) 129 (2): 177–183.
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H. Straaten, K. J. Weber, J. Kiefer; Protein Synthesis in Irradiated Cells: I. Ultraviolet Radiation. Radiat Res 1 February 1992; 129 (2): 177–183. doi: https://doi.org/10.2307/3578155
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