The radiation chemistry in aqueous solution of the dinucleoside monophosphate d-[CpT] and its sequence isomer d-[TpC] in air or nitrogen was examined using different qualities and quantities of radiations. High-performance liquid chromatography and gas chromatography-mass spectrometry were used to analyze the high-energy electron (13.2 MeV) exposure products or fission-neutron exposure products of d-[CpT] and d-[TpC]. A comparison of product profiles obtained from irradiated d-[CpT] and d-[TpC] suggests that, at relatively low radiation doses (50-250 Gy), products are formed by N-glycosidic or phosphodiester bond-cleavage, while at higher doses (500-1000 Gy) additional products were detected as a consequence of ring-modification mechanisms. The plots of radiation dose-yield and corresponding calculated G values of the released undamaged bases and nucleosides from d-[CpT] and d-[TpC] suggest a base-sequence dependence and a quality- and quantity-dependent response to ionizing radiation. Although the product quantities formed from sequence isomers were slightly different, we found no qualitative differences in the product formed at the lowest doses examined.
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Research Article| January 01 1993
Radiolysis in Aqueous Solution of Dinucleoside Monophosphates by High-Energy Electrons and Fission Neutrons
Radiat Res (1993) 133 (1): 12–19.
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Y. N. Vaishnav, C. E. Swenberg; Radiolysis in Aqueous Solution of Dinucleoside Monophosphates by High-Energy Electrons and Fission Neutrons. Radiat Res 1 January 1993; 133 (1): 12–19. doi: https://doi.org/10.2307/3578251
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