This is the final report of a detailed study of the interaction of 670A MeV neon ions with water, used as a presumed tissue-equivalent target. A first comparison of the data with theoretical fluence spectra predicted by the one-generation heavy-ion transport code HZESEC was reported previously. In the present article, subsequent nuclear interactions of the fragment are taken into account, using the LBLBEAM multigeneration heavy-ion transport code, which incorporated new features and modifications intended to address some of the approximations made in the previous calculation. The LBLBEAM code uses the method of characteristics and an iterative procedure to solve a one-dimensional Boltzmann transport equation for the first through third successive generations of nuclear reaction products; it includes a recent version of the semiempirical model used to derive nuclear interaction cross sections. The stopping power used for the theory was calculated in the same way that experimental time-of-flight and energy-loss data are converted to obtain a comparison independent of stopping power; accordingly, good agreement was found between calculated and measured neon fluence spectra in the Bragg peak region. Multiple scattering effects were considered separately for each isotope in the present work. Acceptance factors were calculated as previously, assuming that all projectile fragments originate from the first nuclear interaction. The results show that lower-mass isotopes can account for the high-LET portions of the spectrum in measured fluence spectra. Third-generation products become increasingly important as a source of lighter fragments for depths comparable with the primary particle mean free path, accounting for between one-third and one-half of carbon and lighter particles near the Bragg peak; higher-order interactions were negligible for the detector geometry and meterial thicknesses examined. Agreement between measured and calculated fluence spectra is 30% (20% for integral fluences). Inclusion of hydrogen, helium, and lithium fragments improves agreement between calculated and measured RBE values for spermatogonial cell survival, but tertiary particle acceptance and track structure effects need to be understood in greater detail to predict RBE accurately.

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