Induction of mutation to 6-thioguanine resistance was studied in cultured near-diploid mouse cells (m5S) in plateau and log phase after exposure to γ rays at dose rates of 30 Gy/h, 180 mGy/h, or 13 mGy/h. In plateau-phase culture, lowering the dose rate from 30 Gy/h to 13 mGy/h resulted in an increase in cell survival and a marked decrease in induced mutation frequency. On the other hand, in the log-phase culture, the magnitude of the dose-rate effects was not as marked as in the plateau-phase culture, particularly within a dose range below 5 Gy. These results, together with those indicating the inverse dose-rate effects in growing mouse leukemia cells (Radiat Res. 115, 273-280, 1988), demonstrate the significant influence of cell growth that takes place during protracted irradiation, particularly for the induction of mutation.
Mutation Induction by Different Dose Rates of Gamma Rays in Near-Diploid Mouse Cells in Plateau- and Log-Phase Culture
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Ikuko Furuno-Fukushi, Kazuko Aoki, Hiromichi Matsudaira; Mutation Induction by Different Dose Rates of Gamma Rays in Near-Diploid Mouse Cells in Plateau- and Log-Phase Culture. Radiat Res 1 October 1993; 136 (1): 97–102. doi: https://doi.org/10.2307/3578645
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