This study investigated whether tetrachlorodecaoxide (TCDO), a potent wound-healing agent, promotes recovery of hematopoietic tissue of mice depleted by sublethal X irradiation. Mice were exposed to 3 Gy total-body irradiation and were given 1 ml/kg TCDO intravenously daily from day 1 to 5 or day 4 to 8 after irradiation. The effect was assessed by the change in the total number of nucleated cells in bone marrow and spleen, endogenous spleen colony formation, and 30-day mouse lethality. In the spleen there were profound effects on spleen weight, total organ cellularity, and endogenous colony formation. The TCDO produced radiation dose-modifying factors between 1.4 and 1.5 for endogenous spleen colony formation in mice primed with 3 Gy and reirradiated 4 days after treatment. This stimulated cellular recovery resulted in an increased protection of mice from lethality caused by subsequent total-body irradiation by factors of 1.12-1.18. The results show that TCDO is a potent stimulator of cellular recovery in the spleen of sublethally irradiated mice.
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Research Article| November 01 1993
Stimulation of Hematopoietic Cell Recovery by Tetrachlorodecaoxide in Sublethally Irradiated Mice
Kathryn A. Mason ;
Sandra Murphy ;
Radiat Res (1993) 136 (2): 229–235.
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Kathryn A. Mason, Sandra Murphy, Luka Milas; Stimulation of Hematopoietic Cell Recovery by Tetrachlorodecaoxide in Sublethally Irradiated Mice. Radiat Res 1 November 1993; 136 (2): 229–235. doi: https://doi.org/10.2307/3578615
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