An ionizing radiation-sensitive mutant of CHO cells, irs-20, irradiated in plateau-phase cultures showed a complete lack of a dose-rate effect, i.e., there was no reduction in cell killing per unit dose as the dose rate was lowered from 0.75 Gy/min to 0.06 Gy/h. No measurable repair of potentially lethal damage or sublethal damage was evident for irs-20 cells in the G1 phase of the cell cycle. During S phase, irs-20 cells showed repair of sublethal damage similar to that for the wild-type cells.
An Ionizing Radiation-Sensitive Mutant of CHO Cells: irs-20: II. Dose-Rate Effects and Cellular Recovery Processes
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M. A. Stackhouse, J. S. Bedford; An Ionizing Radiation-Sensitive Mutant of CHO Cells: irs-20: II. Dose-Rate Effects and Cellular Recovery Processes. Radiat Res 1 November 1993; 136 (2): 250–254. doi: https://doi.org/10.2307/3578618
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