The universal use of dose as a normalizing parameter in radiobiology is based entirely on the availability of measuring instruments. It is a poor basis for predicting or understanding the relationship between an irradiation and the resulting end point. Energy deposited is not the cause of an interaction. It is a secondary effect. The interaction is best described by fluence and cross section. Energy deposited depends principally upon inelastic collision cross sections for the interaction of electrons with molecules. Especially for heavy-ion bombardments, for high-LET radiations, inelastic electron collision cross sections relate only remotely to the observed end points of interest. When dose is used to describe effects observed with radiations of different "quality," response predictions can be very wide of the mark. One way to describe such a relationship is through the relative biological effectiveness (RBE). If we consider the RBE to be a correction factor to be applied to a prediction of response based on dose, we find that its values range from 0.01 to infinity. It is apparent that in general dose is a useless predictor of response, except in narrowly defined circumstances.
Skip Nav Destination
- Views Icon Views
- Share Icon Share
- Search Site
Robert Katz; Dose. Radiat Res 1 March 1994; 137 (3): 410–413. doi: https://doi.org/10.2307/3578718
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner
Photon GRID Radiation Therapy: A Physics and Dosimetry White Paper from the Radiosurgery Society (RSS) GRID/LATTICE, Microbeam and FLASH Radiotherapy Working Group
Hualin Zhang, Xiaodong Wu, Xin Zhang, Sha X. Chang, Ali Megooni, Eric D. Donnelly, Mansoor M. Ahmed, Robert J. Griffin, James S. Welsh, Charles B. Simone, II, Nina A. Mayr