Precursor frequencies of cytotoxic lymphocytes to autologous Epstein-Barr virus-transformed B cells and serum titers of anti-Epstein-Barr virus-related antibodies were measured in 68 atomic bomb survivors to clarify the immune mechanism controlling Epstein-Barr virus infection. The precursor frequency was negatively correlated with the titer of anti-early antigen IgG, which is probably produced at the stage of viral reactivation. A positive correlation between the precursor frequency and titer of anti-Epstein-Barr virus-associated nuclear antigen antibody was also observed, indicating that the precursor frequency reflects the degree of in vivo destruction by T cells of the virus-infected cells. These results suggest that T-cell memory specific to Epstein-Barr virus keeps the virus under control and that the precursor frequency assay is useful for the evaluation of immune responses to Epstein-Barr virus. However, no significant effect of atomic bomb radiation on the precursor frequency was observed in the present study, probably due to the limited number of participants.
Immune Responses to Epstein-Barr Virus in Atomic Bomb Survivors: Study of Precursor Frequency of Cytotoxic Lymphocytes and Titer Levels of Anti-Epstein-Barr Virus-Related Antibodies
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Yoichiro Kusunoki, Seishi Kyoizumi, Yasuko Fukuda, Hua Huang, Mayumi Saito, Kyoko Ozaki, Yuko Hirai, Mitoshi Akiyama; Immune Responses to Epstein-Barr Virus in Atomic Bomb Survivors: Study of Precursor Frequency of Cytotoxic Lymphocytes and Titer Levels of Anti-Epstein-Barr Virus-Related Antibodies. Radiat Res 1 April 1994; 138 (1): 127–132. doi: https://doi.org/10.2307/3578856
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