Rats exposed to 0.1-5 Gy of heavy particles (<tex-math>${}^{56}{\rm Fe}$</tex-math>, <tex-math>${}^{40}{\rm Ar}$</tex-math>, <tex-math>${}^{20}{\rm Ne}$</tex-math> or^{4} He) showed dose-dependent changes in body temperature. Lower doses of all particles produced hyperthermia, and higher doses of <tex-math>${}^{20}{\rm Ne}$</tex-math> and <tex-math>${}^{56}{\rm Fe}$</tex-math> produced hypothermia. Of the four HZE particles, <tex-math>${}^{56}{\rm Fe}$</tex-math> particles were the most potent and^{4} He particles were the least potent in producing changes in thermoregulation. The <tex-math>${}^{20}{\rm Ne}$</tex-math> and <tex-math>${}^{40}{\rm Ar}$</tex-math> particles produced an intermediate level of change in body temperature. Significantly greater hyperthermia was produced by exposure to 1 Gy of <tex-math>${}^{20}{\rm Ne}$</tex-math>, <tex-math>${}^{40}{\rm Ar}$</tex-math> and <tex-math>${}^{56}{\rm Fe}$</tex-math> particles than by exposure to 1 Gy of^{60} Co γ rays. Pretreating rats with the cyclo-oxygenase inhibitor indomethacin attenuated the hyperthermia produced by exposure to 1 Gy of <tex-math>${}^{56}{\rm Fe}$</tex-math> particles, indicating that prostaglandins mediate <tex-math>${}^{56}{\rm Fe}\text{-particle-induced}$</tex-math> hyperthermia. The hypothermia produced by exposure to 5 Gy of <tex-math>${}^{56}{\rm Fe}$</tex-math> particles is mediated by histamine and can be attenuated by treatment with the antihistamines mepyramine and cimetidine.

Skip Nav Destination

Close

Article navigation

September 1994

Research Article|
September 01 1994

# Exposure to Heavy Charged Particles Affects Thermoregulation in Rats

*Radiat Res*(1994) 139 (3): 352–356.

Citation

Sathasiva B. Kandasamy, Bernard M. Rabin, Walter A. Hunt, Thomas K. Dalton, James A. Joseph, Alan H. Harris; Exposure to Heavy Charged Particles Affects Thermoregulation in Rats. * Radiat Res* 1 September 1994; 139 (3): 352–356. doi: https://doi.org/10.2307/3578833

Download citation file:

Close

## Sign in

Don't already have an account? Register

### Client Account

You could not be signed in. Please check your email address / username and password and try again.

### Sign in via your Institution

Sign in via your Institution### Citing articles via

Commonalities Between COVID-19 and Radiation Injury

Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo

Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?

Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held

Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light

Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner