Chromosome aberrations induced in vivo were studied in nine children 5-12 years old treated with total-body high-energy photon irradiation (pulsed exposure from a LINAC) for different types of malignant diseases. Dose-effect relationships were obtained for each child by taking blood at different times during exposure. In vitro dose-effect relationships for chromosome aberrations in children and adults were obtained by exposing blood under the same conditions as the children. Exposure in vivo and in vitro yielded similar linear-quadratic dose-effect relationships for dicentric aberrations. The response in vitro was slightly greater than in vivo, but the difference was not very large. It is concluded that the dose-effect relationship for dicentric chromosome aberrations obtained in vitro for adults can be used for biological dosimetry in irradiated children. Some of the children displayed a high number of "rogue cells" before exposure; this may be due to the malignant disease as it was not found in the healthy controls.
Dose-Effect Relationship for In Vivo and In Vitro Induction of Dicentric Aberrations in Blood Lymphocytes of Children
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A. Léonard, I. Baltus, E. D. Léonard, G. B. Gerber, F. Richard, A. Wambersie; Dose-Effect Relationship for In Vivo and In Vitro Induction of Dicentric Aberrations in Blood Lymphocytes of Children. Radiat Res 1 January 1995; 141 (1): 95–98. doi: https://doi.org/10.2307/3579096
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