A novel immunosuppressant, deoxyspergualin, given at doses of 2.5 to 20 mg/kg/day on days -3, -2 and -1 before X irradiation protected BALB/c mice from the lethal effects of radiation in a dose-dependent manner. The dose of radiation that killed 50% of the mice within 30 days was 5.63 Gy for mice receiving radiation alone, but was 7.13 Gy in the mice given deoxyspergualin at 20 mg/kg. Prior administration of deoxyspergualin ameliorated leukopenia and thrombocytopenia induced by sublethal irradiation, and significantly increased the number of femoral spleen colony-forming units (CFU-S) that survived irradiation. Deoxyspergualin also reduced the proportion of CFU-S in S phase, as determined by in vitro sensitivity to hydroxyurea. These findings suggest that deoxyspergualin may be effective in the prevention of hematopoietic injury caused by radiotherapy.
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Research Article| February 01 1995
Deoxyspergualin Is a New Radioprotector in Mice
Kyuichi Nemoto ;
Kazuyuki Horiuchi ;
Radiat Res (1995) 141 (2): 223–226.
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Kyuichi Nemoto, Kazuyuki Horiuchi, Tadaaki Miyamoto; Deoxyspergualin Is a New Radioprotector in Mice. Radiat Res 1 February 1995; 141 (2): 223–226. doi: https://doi.org/10.2307/3579052
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