This report extends our investigation of double base lesions produced by irradiation of DNA model compounds. Studies of d(CpGpTpA) X-irradiated in oxygenated aqueous solution show that two of the five principal products are oligomers having adjacent bases damaged. In these oligomers guanine is hydroxylated at the 8-position and an adjacent pyrimidine is degraded to a formamido remnant.
The Radiation Chemistry of d(CpGpTpA) in the Presence of Oxygen
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Edwin E. Budzinski, Jean D. Dawidzik, John C. Wallace, Harold G. Freund, Harold C. Box; The Radiation Chemistry of d(CpGpTpA) in the Presence of Oxygen. Radiat Res 1 April 1995; 142 (1): 107–109. doi: https://doi.org/10.2307/3578973
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