Hypoxic fractions were measured in multiple tumor models and compared to31 P magnetic resonance spectroscopy (MRS) parameters. Hypoxic fractions were measured by excision assays in intramuscular and subcutaneous RIF-1 tumors, large and small SCCVII tumors, and KHT tumors. The hypoxic fractions ranged from 3% (small SCCVII) to 21% (KHT). Measurements of31 P MRS parameters (indices of tumor metabolism) were made under the same conditions used in the hypoxic fraction assays. The <tex-math>${\rm PCr}/{\rm P}_{{\rm i}}$</tex-math> ratios in the five tumor models were strongly correlated r2=0.98, τ = 1.00, P < 0.02) with their hypoxic fractions, and the <tex-math>${\rm NTP}/{\rm P}_{{\rm i}}$</tex-math> ratio was weakly correlated (r2=0.67, τ = 0.60, P < 0.17) with hypoxic fraction. Smaller values of the <tex-math>${\rm PCr}/{\rm P}_{{\rm i}}$</tex-math> and <tex-math>${\rm NTP}/{\rm P}_{{\rm i}}$</tex-math> ratios were found in the tumors with larger hypoxic fractions. These experiments indicate that31 P MRS may provide a relative measurement of hypoxic fractions across different tumor lines that can be applied non-invasively to individual tumors.
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July 1995
Research Article|
July 01 1995
Correlation of Radiobiological Assays of Hypoxic Fraction with Phosphorus-31 Magnetic Resonance Spectroscopy across Multiple Tumor Lines
Radiat Res (1995) 143 (1): 45–53.
Citation
Shi-Jiang Li, Guan-Yuan Jin, Brian L. Fish, John E. Moulder; Correlation of Radiobiological Assays of Hypoxic Fraction with Phosphorus-31 Magnetic Resonance Spectroscopy across Multiple Tumor Lines. Radiat Res 1 July 1995; 143 (1): 45–53. doi: https://doi.org/10.2307/3578924
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