The effects of γ radiation on the stability and size of mammalian DNA were studied by using thermal transition spectrophotometry and pulsed-field and standard agarose gel electrophoresis. The experiments were performed using deproteinized calf thymus DNA in buffered deaerated aqueous solutions. A dual dose response was observed: a tendency for increased helix stability at "low" doses (0-4 Gy) accompanied by a high tendency of the DNA molecules to interact, forming larger molecules, followed by a gradual increase of degradation and helix instability at higher doses. The results reported here for the low-dose region are consistent with the hypothesis of inter- and intramolecular interactions of covalent character (crosslinking) in irradiated DNA molecules.
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Research Article| October 01 1998
Effects of Gamma Rays on the Stability and Size of DNA
A. G. Georgakilas ;
L. Sakelliou ;
E. G. Sideris ;
L. H. Margaritis ;
Radiat Res (1998) 150 (4): 488–491.
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A. G. Georgakilas, L. Sakelliou, E. G. Sideris, L. H. Margaritis, V. Sophianopoulou; Effects of Gamma Rays on the Stability and Size of DNA. Radiat Res 1 October 1998; 150 (4): 488–491. doi: https://doi.org/10.2307/3579670
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