We have tested an 836.55 MHz field with North American Digital Cellular (NADC) modulation in a 2-year animal bioassay that included fetal exposure. In offspring of pregnant Fischer 344 rats, we tested both spontaneous tumorigenicity and the incidence of induced central nervous system (CNS) tumors after a single dose of the carcinogen ethylnitrosourea (ENU) in utero, followed by intermittent digital-phone field exposure for 24 months. Far-field exposures began on gestational day 19 and continued until weaning at age 21 days. Near-field exposures began at 35 days and continued for the next 22 months, 4 consecutive days weekly, 2 h/day. SAR levels simulated localized peak brain exposures of a cell phone user. Of the 236 original rats, 182 (77%) survived to the termination of the whole experiment and were sacrificed at age 709-712 days. The 54 rats (23%) that died during the study ("preterm rats") formed a separate group for some statistical analyses. There was no evidence of tumorigenic effects in the CNS from exposure to the TDMA field. However, some evidence of tumor-inhibiting effects of TDMA exposure was apparent. Overall, the TDMA field-exposed animals exhibited trends toward a reduced incidence of spontaneous CNS tumors (P < 0.16, two-tailed) and ENU-induced CNS tumors (P < 0.16, two-tailed). In preterm rats, where primary neural tumors were determined to be the cause of death, fields decreased the incidence of ENU-induced tumors (P < 0.03, two-tailed). We discuss a possible approach to evaluating with greater certainty the possible inhibitory effects of TDMA-field exposure on tumorigenesis in the CNS.
Spontaneous and Nitrosourea-Induced Primary Tumors of the Central Nervous System in Fischer 344 Rats Chronically Exposed to 836 MHz Modulated Microwaves
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W. R. Adey, C. V. Byus, C. D. Cain, R. J. Higgins, R. A. Jones, C. J. Kean, N. Kuster, A. MacMurray, R. B. Stagg, G. Zimmerman, J. L. Phillips, W. Haggren; Spontaneous and Nitrosourea-Induced Primary Tumors of the Central Nervous System in Fischer 344 Rats Chronically Exposed to 836 MHz Modulated Microwaves. Radiat Res 1 September 1999; 152 (3): 293–302. doi: https://doi.org/10.2307/3580329
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