The authors of the above critique are concerned that we are presenting evidence that calls into question some of the key assumptions underlying their landmark studies of DNA misrejoining after ultra-high doses of ionizing radiation. We have been studying DNA repair for many years using techniques very similar to the ones required for these studies, and we had hoped to be able to extend our work to quantify misrejoining in double-minute chromosomes. Unfortunately, our results suggest that the ultra-high doses of ionizing radiation lead to artifacts that could easily be misinterpreted as misrejoining. We would have much preferred that our results support those of Löbrich et al. (1).

The authors of the critique suggest that it is not possible to draw conclusions about misrejoining based on our results. We essentially came to the same conclusion in our paper. The question, however, is...

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