Wolf, C., Lafuma, J., Masse, R., Morin, M. and Kellerer, A. M. Neutron RBE for Induction of Tumors with High Lethality in Sprague-Dawley Rats.
The effectiveness of fission neutrons is compared to that of γ rays and X rays with regard to the induction of malignancies in male Sprague-Dawley rats. The analysis is based on autopsy results. It is focused on tumors that tend to be present in animals dying early, which is indicative of a high degree of lethality. The relative biological effectiveness (RBE) is deduced from a comparison of the cumulative hazard functions. Different nonparametric models—the constant relative risk model, a time shift model, and an acceleration model—are employed in the comparison, and the resulting values of RBE are seen to be substantially independent of the choice of model. The results are in good agreement with earlier studies of nonlethal lung tumors in the same series of experiments. At neutron doses of 20 to 60 mGy, the RBE of fission neutrons is about 50.