We have several comments about the paper entitled “No Lengthening of Life Span in Mice Continuously Exposed to Gamma Rays at Very Low Dose Rates” by Tanaka et al. (1). This paper presents valuable data from whole-body experiments that are needed to examine the present framework of radiation protection. The results were obtained with the strong support of experts and were supported by public grants.

The study was performed using 4000 SPF mice in a strictly controlled environment during the whole life span of the mice with various radiation exposure levels. The authors state that the purpose of the study is to evaluate the biological effects of low-dose-rate radiation using life span and neoplasm incidence as parameters. They reached the conclusion that so far as the life span of mice is concerned their results show no evidence of an adaptive response or of a threshold.

We think...

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