Shortly after reading the article by Bijwaard et al. (1), we responded (01 February 2005) to them by letter and received a courteous reply from Dr. Bijwaard on 29 April 2005. He agreed with many of our comments and said he would keep us informed about any new activities they might pursue with regard to our dog studies. It will be attempted herein to restate succinctly the comments made in our letter.

In their article, they used data from the beagle project at the University of Utah, along with data from other projects, as input for their models of bone cancer induction by radionuclide exposure in comparison with that in humans. However, they counted only osteosarcomas in dogs but all skeletal malignancies in humans. In numerous reports from this laboratory [ref. (2) is a recent example] about bone tumors in beagles,...

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