In the coming decades human space exploration is expected to move beyond low-Earth orbit. This transition involves increasing mission time and therefore an increased risk of radiation exposure from solar particle event (SPE) radiation. Acute radiation effects after exposure to SPE radiation are of prime importance due to potential mission-threatening consequences. The major objective of this study was to characterize the dose–response relationship for proton and γ radiation delivered at doses up to 2 Gy at high (0.5 Gy/min) and low (0.5 Gy/h) dose rates using white blood cell (WBC) counts as a biological end point. The results demonstrate a dose-dependent decrease in WBC counts in mice exposed to high- and low-dose-rate proton and γ radiation, suggesting that astronauts exposed to SPE-like radiation may experience a significant decrease in circulating leukocytes.
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1 August 2011
REGULAR ARTICLES|
April 08 2011
Analysis of White Blood Cell Counts in Mice after Gamma- or Proton-Radiation Exposure
Casey J. Maks;
Casey J. Maks
aDepartment of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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X. Steven Wan;
X. Steven Wan
aDepartment of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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Jeffrey H. Ware;
Jeffrey H. Ware
aDepartment of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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Ana L. Romero-Weaver;
Ana L. Romero-Weaver
aDepartment of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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Jenine K. Sanzari;
Jenine K. Sanzari
aDepartment of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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Jolaine M. Wilson;
Jolaine M. Wilson
aDepartment of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
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Steve Rightnar;
Steve Rightnar
bDepartment of Radiation Medicine, Chan Shun Pavilion Room A-1010, 11175 Campus Street, Loma Linda University, Loma Linda, California 92354
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Andrew J. Wroe;
Andrew J. Wroe
bDepartment of Radiation Medicine, Chan Shun Pavilion Room A-1010, 11175 Campus Street, Loma Linda University, Loma Linda, California 92354
cCenter for Medical Radiation Physics, University of Wollongong, Wollongong, NSW, Australia 2522
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Peter Koss;
Peter Koss
bDepartment of Radiation Medicine, Chan Shun Pavilion Room A-1010, 11175 Campus Street, Loma Linda University, Loma Linda, California 92354
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Daila S. Gridley;
Daila S. Gridley
bDepartment of Radiation Medicine, Chan Shun Pavilion Room A-1010, 11175 Campus Street, Loma Linda University, Loma Linda, California 92354
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James M. Slater;
James M. Slater
bDepartment of Radiation Medicine, Chan Shun Pavilion Room A-1010, 11175 Campus Street, Loma Linda University, Loma Linda, California 92354
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Ann R. Kennedy
Ann R. Kennedy
1
aDepartment of Radiation Oncology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania
1Address for correspondence: 195 John Morgan Building, 3620 Hamilton Walk, Philadelphia, PA 19104-6072; e-mail: akennedy@mail.med.upenn.edu.
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Radiat Res (2011) 176 (2): 170–176.
Article history
Received:
August 13 2010
Accepted:
February 28 2011
Citation
Casey J. Maks, X. Steven Wan, Jeffrey H. Ware, Ana L. Romero-Weaver, Jenine K. Sanzari, Jolaine M. Wilson, Steve Rightnar, Andrew J. Wroe, Peter Koss, Daila S. Gridley, James M. Slater, Ann R. Kennedy; Analysis of White Blood Cell Counts in Mice after Gamma- or Proton-Radiation Exposure. Radiat Res 1 August 2011; 176 (2): 170–176. doi: https://doi.org/10.1667/RR2413.1
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