Protection against radiation-induced DNA strand breaks is an important aspect in the design and development of a radioprotector. In this study, the radioprotective efficacy of sesamol, a natural antioxidant, was investigated in aqueous solution of plasmid DNA (pBR322) and compared with that of melatonin, a known antioxidant-based radioprotector. Thermal denaturation studies on irradiated calf thymus DNA were also carried out with sesamol and melatonin. Sesamol demonstrated greater radioprotective efficacy in both plasmid DNA and calf thymus DNA. To assess the radical scavenging capacity of sesamol and melatonin, 2-deoxyribose degradation, DPPH and ABTS assays were performed. Sesamol exhibited more scavenging capacity compared to melatonin. In vitro studies with V79 cells showed that sesamol is 20 times more potent than melatonin. It is proposed that the greater radioprotective efficacy of sesamol could be due to its greater capacity for scavenging of free radicals compared to melatonin. The results will be helpful in understanding the mechanisms and development of sesamol as a radioprotector.
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other| September 07 2011
Sesamol as a Potential Radioprotective Agent: In Vitro Studies
P. S. Srivastava;
N. K. Chaudhury
N. K. Chaudhury 1
a Chemical Radioprotector and Radiation Dosimetry Research Group, Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi 110054, India; and
1 Address for correspondence: Chemical Radioprotector and Radiation Dosimetry Research Group, Division of Radiation Biosciences, Institute of Nuclear Medicine and Allied Sciences, Delhi 110054, India; e-mail: email@example.com.
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K. Mishra, P. S. Srivastava, N. K. Chaudhury; Sesamol as a Potential Radioprotective Agent: In Vitro Studies. Radiat Res 1 November 2011; 176 (5): 613–623. doi: https://doi.org/10.1667/RR2661.1
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