Whole body irradiated mice appear to experience a down-regulation of the helper T (Th)1-like immune response, and maintain a persistent immunological imbalance. In the current study, we evaluated the effect of HemoHIM (an herbal product made from Angelica Radix, Cnidium officinale, and Paeonia japonica cultivated in Korea) to ameliorate the immunological imbalance induce in fractionated γ-irradiated mice. The mice were exposed to γ rays twice a week (0.5 Gy fractions) for a total dose of 5 Gy, and HemoHIM was administrated orally from 1 week before the first irradiation to 1 week before the final analysis. All experiments were performed 4 and 6 months after their first exposure. HemoHIM ameliorated the Th1- and Th2-related immune responses normally occur in irradiated mice with or without dinitrophenylated keyhole limpet hemocyanin immunization. HemoHIM also restored the natural killer cell activities without changing the percentage of natural killer cells in irradiated mice. Furthermore, the administration of HemoHIM prevented the reduction in levels of interleukin-12p70 in irradiated mice. Finally, we found that HemoHIM enhanced the phosphorylation of signal transducer and activator of transcription (STAT) 4 that was reduced in irradiated mice. Our findings suggest that HemoHIM ameliorates the persistent down-regulation of Th1-like immune responses by modulating the IL-12p70/pSTAT4 signaling pathway.
Skip Nav Destination
Article navigation
1 May 2012
REGULAR ARTICLES|
March 22 2012
HemoHIM Ameliorates the Persistent Down-Regulation of Th1-like Immune Responses in Fractionated γ-Irradiated Mice by Modulating the IL-12p70-STAT4 Signaling Pathway
Hae-Ran Park;
Hae-Ran Park
Radiation Research Division for Bio-Technology, Jeongeup Campus of Korea Atomic Energy Research Institute (KAERI), 1266 Sinjeong-dong Jeongeup-si Jeonbuk 580-185, Republic of Korea
Search for other works by this author on:
Sung-Kee Jo;
Sung-Kee Jo
1
Radiation Research Division for Bio-Technology, Jeongeup Campus of Korea Atomic Energy Research Institute (KAERI), 1266 Sinjeong-dong Jeongeup-si Jeonbuk 580-185, Republic of Korea
1Address for correspondence: Radiation Research Division for Bio-Technology, Jeongeup Campus of Korea Atomic Energy Research Institute (KAERI), 1266 Sinjeong-dong Jeongeup-si Jeonbuk 580-185, Republic of Korea; e-mail: skjo@kaeri.re.kr.
Search for other works by this author on:
Nam-Hee Choi;
Nam-Hee Choi
Radiation Research Division for Bio-Technology, Jeongeup Campus of Korea Atomic Energy Research Institute (KAERI), 1266 Sinjeong-dong Jeongeup-si Jeonbuk 580-185, Republic of Korea
Search for other works by this author on:
Uhee Jung
Uhee Jung
Radiation Research Division for Bio-Technology, Jeongeup Campus of Korea Atomic Energy Research Institute (KAERI), 1266 Sinjeong-dong Jeongeup-si Jeonbuk 580-185, Republic of Korea
Search for other works by this author on:
Radiat Res (2012) 177 (5): 676–684.
Article history
Received:
August 11 2011
Accepted:
December 09 2011
Citation
Hae-Ran Park, Sung-Kee Jo, Nam-Hee Choi, Uhee Jung; HemoHIM Ameliorates the Persistent Down-Regulation of Th1-like Immune Responses in Fractionated γ-Irradiated Mice by Modulating the IL-12p70-STAT4 Signaling Pathway. Radiat Res 1 May 2012; 177 (5): 676–684. doi: https://doi.org/10.1667/RR2768.1
Download citation file:
Sign in
Don't already have an account? Register
Client Account
You could not be signed in. Please check your email address / username and password and try again.
Could not validate captcha. Please try again.
Sign in via your Institution
Sign in via your InstitutionCiting articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Effects of Radiation on Blood Pressure and Body Weight in the Spontaneously Hypertensive Rat Model. Are Radiation Effects on Blood Pressure Affected by Genetic Background?
Norio Takahashi, Munechika Misumi, Yasuharu Niwa, Hideko Murakami, Waka Ohishi, Toshiya Inaba, Akiko Nagamachi, Satoshi Tanaka, Ignacia Braga Tanaka, III, Gen Suzuki
Exposure to Ionizing Radiation and Risk of Dementia: A Systematic Review and Meta-Analysis
Tanvi Srivastava, Ekaterina Chirikova, Sapriya Birk, Fanxiu Xiong, Tarek Benzouak, Jane Y. Liu, Paul J. Villeneuve, Lydia B. Zablotska
Studies of the Mortality of Atomic Bomb Survivors, Report 14, 1950–2003: An Overview of Cancer and Noncancer Diseases
Kotaro Ozasa, Yukiko Shimizu, Akihiko Suyama, Fumiyoshi Kasagi, Midori Soda, Eric J. Grant, Ritsu Sakata, Hiromi Sugiyama, Kazunori Kodama
Long-Term Effects of the Rain Exposure Shortly after the Atomic Bombings in Hiroshima and Nagasaki
Ritsu Sakata, Eric J. Grant, Kyoji Furukawa, Munechika Misumi, Harry Cullings, Kotaro Ozasa, Roy E. Shore