Alzheimer's disease is a neurodegenerative disorder that becomes more prevalent with increasing age. An estimated 5.2 million Americans have Alzheimer's disease (AD), and by mid-century the number of people living with AD in the United States is projected to reach 9 million (). It is widely acknowledged that Dr. Alois Alzheimer was the first to associate progressive cognitive impairment with the presence of senile plaques and neurofibrillary tangles in the cortex of the brain (2, 3 ). While Dr. Alzheimer's initial report was presented in 1906, the cause, or causes of Alzheimer's disease remain unclear. The complex pathology of AD, the incomplete understanding of brain dysfunction and the lack of a definitive diagnostic test have all hindered the development of clinical treatments for AD. At best, current interventions remain palliative and transient rather than disease modifying, and even fail to slow disease progression to any...

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