Alzheimer's disease is a neurodegenerative disorder that becomes more prevalent with increasing age. An estimated 5.2 million Americans have Alzheimer's disease (AD), and by mid-century the number of people living with AD in the United States is projected to reach 9 million (1 ). It is widely acknowledged that Dr. Alois Alzheimer was the first to associate progressive cognitive impairment with the presence of senile plaques and neurofibrillary tangles in the cortex of the brain (2, 3 ). While Dr. Alzheimer's initial report was presented in 1906, the cause, or causes of Alzheimer's disease remain unclear. The complex pathology of AD, the incomplete understanding of brain dysfunction and the lack of a definitive diagnostic test have all hindered the development of clinical treatments for AD. At best, current interventions remain palliative and transient rather than disease modifying, and even fail to slow disease progression to any...
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Research Article| May 19 2016
A New Use for an Old Treatment: Radiation Therapy and Alzheimer's Disease
George D. Wilson ;
Brian Marples 1
Department of Radiation Oncology, William Beaumont Hospital, Royal Oak, Michigan
1Address for correspondence: Department of Radiation Oncology, William Beaumont Hospital, 3811 W. Thirteen Mile Rd, 105-RI, Royal Oak, Michigan 48073; email: firstname.lastname@example.org.
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George D. Wilson, Brian Marples; A New Use for an Old Treatment: Radiation Therapy and Alzheimer's Disease. Radiat Res 1 May 2016; 185 (5): 443–448. doi: https://doi.org/10.1667/RR14367.1
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