With the possibility of large-scale terrorist attacks around the world, the need for modeling and development of new medical countermeasures for potential future chemical, biological, radiological and nuclear (CBRN) has been well established. Project Bioshield, initiated in 2004, provided a framework to develop and expedite research in the field of CBRN exposures. To respond to large-scale population exposures from a nuclear event or radiation dispersal device (RDD), new methods for determining received dose using biological modeling became necessary. The field of biodosimetry has advanced significantly beyond this original initiative, with expansion into the fields of genomics, proteomics, metabolomics and transcriptomics. Studies are ongoing to evaluate the use of lymphocyte kinetics for dose assessment, as well as the development of field-deployable EPR technology. In addition, expansion of traditional cytogenetic assessment methods through the use of automated platforms and the development of laboratory surge capacity networks have helped to advance our biodefense preparedness. In this review of the latest advances in the field of biodosimetry we evaluate our progress and identify areas that still need to be addressed to achieve true field-deployment readiness.
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review article| October 06 2016
State-of-the-Art Advances in Radiation Biodosimetry for Mass Casualty Events Involving Radiation Exposure
Mary Sproull ;
Kevin Camphausen 1
Radiation Oncology Branch, National Cancer Institute, Bethesda, Maryland
1Address for correspondence: Radiation Oncology Branch, National Cancer Institute, 10 Center Drive 3B42, Bethesda, MD; email: firstname.lastname@example.org.
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Radiat Res (2016) 186 (5): 423–435.
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Mary Sproull, Kevin Camphausen; State-of-the-Art Advances in Radiation Biodosimetry for Mass Casualty Events Involving Radiation Exposure. Radiat Res 1 November 2016; 186 (5): 423–435. doi: https://doi.org/10.1667/RR14452.1
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