In 2008, Serandour et al. reported on their in vitro experiment involving rat plasma samples obtained after an intravenous intake of plutonium citrate. Different amounts of DTPA were added to the plasma samples and the percentage of low-molecular-weight plutonium measured. Only when the DTPA dosage was three orders of magnitude greater than the recommended 30 μmol/kg was 100% of the plutonium apparently in the form of chelate. These data were modeled assuming three competing chemical reactions with other molecules that bind with plutonium. Here, time-dependent second-order kinetics of these reactions are calculated, intended eventually to become part of a complete biokinetic model of DTPA action on actinides in laboratory animals or humans. The probability distribution of the ratio of stability constants for the reactants was calculated using Markov Chain Monte Carlo. These calculations substantiate that the inclusion of more reactions is needed in order to be in agreement with known stability constants.
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1 January 2018
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November 15 2017
Second-order Kinetics of DTPA and Plutonium in Rat Plasma
Deepesh Poudel;
Deepesh Poudel
1
bRadiation Protection Division, Los Alamos National Laboratory, Los Alamos, New Mexico
1Address for correspondence: PO Box 1663, MS G761, Los Alamos, NM 87545; email: dpoudel@lanl.gov.
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John A. Klumpp;
John A. Klumpp
bRadiation Protection Division, Los Alamos National Laboratory, Los Alamos, New Mexico
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Raymond A. Guilmette;
Raymond A. Guilmette
cRay Guilmette and Associates, LLC, Perry, Maine
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Dunstana Melo
Dunstana Melo
dMelohill Technology, LLC, Rockville, Maryland
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Radiat Res (2018) 189 (1): 64–67.
Article history
Received:
June 07 2017
Accepted:
September 14 2017
Citation
Guthrie Miller, Deepesh Poudel, John A. Klumpp, Raymond A. Guilmette, Dunstana Melo; Second-order Kinetics of DTPA and Plutonium in Rat Plasma. Radiat Res 1 January 2018; 189 (1): 64–67. doi: https://doi.org/10.1667/RR14852.1
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