In this study, we sought to determine how diffusion-weighted imaging (DWI) and proton magnetic resonance spectroscopy (1H-MRS) features are associated with histopathological results, and explored the cellular mechanisms of DWI and 1H-MRS in early radiosensitivity of transplanted liver tumors. VX2 tumors were implanted into the hind leg muscles of 60 New Zealand White Rabbits. All rabbits were randomly divided into ten subgroups according to treatment: irradiated or nonirradiated and according to different times postirradiation. Magnetic resonance scanning was then performed one day before irradiation and on days 1, 3, 5 and 7 postirradiation. Differences in tumor volume, apparent diffusion coefficient (ADC) value, choline/creatine ratio and lipid/creatine ratio, and their associations with histopathological findings, were assessed. Tumor volumes in the irradiated groups were smaller than control values, while ADC values increased gradually with time postirradiation; choline/creatine ratios were reduced while lipid/creatine ratios were larger compared to control values. Bax protein levels after irradiation increased with time. Interestingly, the ADC value and Bax-positive grade showed the same increasing trend (r = 0.900, P < 0.001). Additionally, choline/creatine and lipid/creatine ratios were respectively significantly associated with Bax-positive grade. Furthermore, significant associations of tumor volume with ADC value, choline/creatine ratio and lipid/creatine ratio were observed. These findings demonstrated that ADC value, choline/creatine ratio and lipid/creatine ratio, indicators of early radiosensitivity, are related to cell apoptosis.
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1 January 2019
Research Article|
October 30 2018
Early Diffusion-Weighted Imaging and Proton Magnetic Resonance Spectroscopy Features of Liver Transplanted Tumors Treated with Radiation in Rabbits: Correlation with Histopathology
Yueming Li
;
aDepartment of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China
1Address for correspondence: Department of Radiology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, 350005, Fujian Province, China; email: fjmulym@163.com.
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Dandan Lin
;
Dandan Lin
2
bDepartment of Radiology, Longyan First Hospital of Fujian Province, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian, 364000, China
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Youliang Weng
;
Youliang Weng
cDepartment of Radiation Oncology, Fujian Provincial Cancer Hospital, the Teaching Hospital of Fujian Medical University, Fuzhou 350014, China
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Shuping Weng
;
Shuping Weng
dDepartment of Radiology, Fujian Provincial Maternity and Child Health Hospital, Fuzhou, Fujian, 350001,China
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Chuan Yan
;
Chuan Yan
aDepartment of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China
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Xuru Xu
;
Xuru Xu
aDepartment of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China
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Jianwei Chen
;
Jianwei Chen
aDepartment of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China
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Rongping Ye
;
Rongping Ye
aDepartment of Radiology, First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian, 350005, China
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Jinsheng Hong
Jinsheng Hong
eKey Laboratory of Radiation Biology (Fujian Medical University), Fujian Province University, Department of Radiation Oncology, the First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, China
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Radiat Res (2019) 191 (1): 52–59.
Article history
Received:
May 21 2018
Accepted:
October 03 2018
Citation
Yueming Li, Dandan Lin, Youliang Weng, Shuping Weng, Chuan Yan, Xuru Xu, Jianwei Chen, Rongping Ye, Jinsheng Hong; Early Diffusion-Weighted Imaging and Proton Magnetic Resonance Spectroscopy Features of Liver Transplanted Tumors Treated with Radiation in Rabbits: Correlation with Histopathology. Radiat Res 1 January 2019; 191 (1): 52–59. doi: https://doi.org/10.1667/RR15140.1
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