In this work, a baseline compartmental model of the distribution and retention of americium in the rat for a systemic intake was derived. The model was derived from data obtained from a study designed to evaluate the behavior of americium in the first 28 days after incorporation. A pharmacokinetic (PK)-front-end modeling approach was used to specify transfer to and from the extracellular fluids (ECF) in the various tissues in terms of vascular flow and volumes of ECF. Back-end rates representing transport into and out of the cells were determined empirically. Uncertainties in transfer rates were investigated using Markov chain Monte Carlo (MCMC). The combination of PK-front-end model and the back-end model structure used allowed for extrapolation to the earliest times with small uncertainty. This approach clearly demonstrated the rapid transfer of material from ECF to liver and bone. This model provides a baseline for modeling the action of decorporation agents, such as DTPA.
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1 July 2019
Research Article|
May 20 2019
Americium Systemic Biokinetic Model for Rats
John A. Klumpp;
John A. Klumpp
1
bRadiation Protection Division, Los Alamos National Laboratory, Los Alamos, New Mexico
1Address for correspondence: P.O. Box 1663, MS G761, Los Alamos, NM 87545; email: jaklumpp@lanl.gov.
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Deepesh Poudel;
Deepesh Poudel
bRadiation Protection Division, Los Alamos National Laboratory, Los Alamos, New Mexico
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Waylon Weber;
Waylon Weber
cLovelace Respiratory Research Institute, Albuquerque, New Mexico
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Raymond A. Guilmette;
Raymond A. Guilmette
dRay Guilmette and Associates, LLC, Perry, Maine
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Jasen Swanson;
Jasen Swanson
eIdaho State University, Pocatello, Idaho
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Dunstanta R. Melo
Dunstanta R. Melo
fMelohill Technology, LLC, Rockville, Maryland
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Radiat Res (2019) 192 (1): 75–91.
Article history
Received:
October 01 2018
Accepted:
April 18 2019
Citation
Guthrie Miller, John A. Klumpp, Deepesh Poudel, Waylon Weber, Raymond A. Guilmette, Jasen Swanson, Dunstanta R. Melo; Americium Systemic Biokinetic Model for Rats. Radiat Res 1 July 2019; 192 (1): 75–91. doi: https://doi.org/10.1667/RR15256.1
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