In response to concerns over possible radiological or nuclear incidents, the Radiation and Nuclear Countermeasures Program within the National Institute of Allergy and Infectious Diseases (NIAID) was tasked by the U.S. Department of Health and Human Services to support development of medical countermeasures (MCM) to treat the acute and delayed injuries that can result from radiation exposure. To date, the only three drugs approved by the U.S. Food and Drug Administration for treatment of acute radiation syndrome are growth factors targeting granulocyte (Neupogen® or Neulasta®) or granulocyte and macrophage (Leukine®) hematopoietic cell lineages. Although these are currently stockpiled for deployment in response to a mass casualty scenario, these growth factors will likely be administered in a scarce-resources environment and availability may be limited. Therefore, there is growing interest in understanding the role that these growth factors play in mitigating radiation damage, to optimize their use and maximize the number of people who can be treated. For these reasons, the NIAID and the Radiation Injury Treatment Network organized a workshop to explore the use of growth factors and other cytokines as MCMs in the treatment of radiation-induced injuries. Subject matter experts from government, industry and academia gathered at this workshop to discuss the concept of operations, triage and treatment, administration to diverse civilian populations, growth factors under development for radiation indications, and how the practice of medicine can inform other potential approaches.
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1 July 2019
Article Commentary|
May 07 2019
Use of Growth Factors and Cytokines to Treat Injuries Resulting from a Radiation Public Health Emergency
Zulmarie Perez Horta
;
Zulmarie Perez Horta
1
aRadiation and Nuclear Countermeasures Program (RNCP), Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland
1Address for correspondence: DAIT, NIAID, NIH, 5601 Fishers Lane, Room 7A61, Rockville, MD 20852; email: zulmarie.perezhorta@nih.gov.
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Cullen M. Case, Jr.
;
Cullen M. Case, Jr.
bRadiation Injury Treatment Network (RITN), Minneapolis, Minnesota
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Andrea L. DiCarlo
Andrea L. DiCarlo
aRadiation and Nuclear Countermeasures Program (RNCP), Division of Allergy, Immunology and Transplantation (DAIT), National Institute of Allergy and Infectious Diseases (NIAID), National Institutes of Health (NIH), Rockville, Maryland
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Radiat Res (2019) 192 (1): 92–97.
Article history
Received:
March 12 2019
Accepted:
April 10 2019
Citation
Zulmarie Perez Horta, Cullen M. Case, Andrea L. DiCarlo; Use of Growth Factors and Cytokines to Treat Injuries Resulting from a Radiation Public Health Emergency. Radiat Res 1 July 2019; 192 (1): 92–97. doi: https://doi.org/10.1667/RR15383.1
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