Experimental studies of cognitive detriments in mice and rats after proton and heavy ion exposures have been performed by several laboratories to investigate possible risks to astronauts exposed to cosmic rays in space travel and patients treated for brain cancers with proton and carbon beams in Hadron therapy. However, distinct radiation types and doses, cognitive tests and rodent models have been used by different laboratories, while few studies have considered detailed dose-response characterizations, including estimates of relative biological effectiveness (RBE). Here we report on the first quantitative meta-analysis of the dose response for proton and heavy ion rodent studies of the widely used novel object recognition (NOR) test, which estimates detriments in recognition or object memory. Our study reveals that linear or linear-quadratic dose-response models of relative risk (RR) do not provide accurate descriptions. However, good descriptions for doses up to 1 Gy are provided by exponentially increasing fluence or dose-response models observed with an LET dependence similar to a classical radiation quality response, which peaks near 100–120 keV/µm and declines at higher LET values. Exponential models provide accurate predictions of experimental results for NOR in mice after mixed-beam exposures of protons and 56Fe, and protons, 16O and 28Si. RBE estimates are limited by available X-ray or gamma-ray experiments to serve as a reference radiation. RBE estimates based on use of data from combined gamma-ray and high-energy protons of low-LET experiments suggest modest RBEs, with values <8 for most heavy ions, while higher values <20 are based on limited gamma-ray data. In addition, we consider a log-normal model for the variation of subject responses at defined dose levels. The log-normal model predicts a heavy ion dose threshold of approximately 0.01 Gy for NOR-related cognitive detriments.
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1 November 2019
Research Article|
August 15 2019
Meta-analysis of Cognitive Performance by Novel Object Recognition after Proton and Heavy Ion Exposures
Eliedonna Cacao
;
Eliedonna Cacao
Department of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, Nevada
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Francis A. Cucinotta
Francis A. Cucinotta
1
Department of Health Physics and Diagnostic Sciences, University of Nevada, Las Vegas, Nevada
1Address for correspondence: University of Nevada, Las Vegas,Department of Diagnostic Sciences and Health Physics, Box 453037, Las Vegas, NV 89195-3037; email: Francis.Cucinotta@unlv.edu.
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Radiat Res (2019) 192 (5): 463–472.
Article history
Received:
April 25 2019
Accepted:
July 18 2019
Citation
Eliedonna Cacao, Francis A. Cucinotta; Meta-analysis of Cognitive Performance by Novel Object Recognition after Proton and Heavy Ion Exposures. Radiat Res 1 November 2019; 192 (5): 463–472. doi: https://doi.org/10.1667/RR15419.1
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