Previously reported studies have revealed that the application of a magnetic field longitudinal to a carbon-ion beam enhances its biological effectiveness. Here we investigated how timing of the magnetic field application with respect to beam irradiation influenced this effect. Human cancer cells were exposed to carbon-ion beams with linear energy transfer (LET) of 12 and 50 keV/µm. The longitudinal magnetic field of 0.3 T was applied to the cells just before, during or immediately after the beam irradiation. The effects of the timing on the biological effectiveness were evaluated by cell survival. The biological effectiveness increased only if the magnetic field was applied during beam irradiation for both LETs.
Effects of Magnetic Field Applied Just Before, During or Immediately after Carbon-Ion Beam Irradiation on its Biological Effectiveness
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Taku Inaniwa, Masao Suzuki, Shinji Sato, Masayuki Muramatsu, Kota Mizushima, Yoshiyuki Iwata, Nobuyuki Kanematsu, Toshiyuki Shirai, Koji Noda; Effects of Magnetic Field Applied Just Before, During or Immediately after Carbon-Ion Beam Irradiation on its Biological Effectiveness. Radiat Res 1 December 2019; 192 (6): 662–665. doi: https://doi.org/10.1667/RR15446.1
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