The radiation-induced bystander effect (RIBE) is a destructive reaction in nonirradiated cells and is one primary factor in determining the efficacy and success of radiation therapy in the field of cancer treatment. Previously reported studies have shown that the RIBE can be mediated by exosomes that carry miRNA components within. Exosomes, which are one type of cell-derived vesicle, exist in different biological conditions and serve as an important additional pathway for signal exchange between cells. In addition, exosome-derived miRNAs are confirmed to play an important role in RIBE, activating the bystander effect and genomic instability after radiotherapy. After investigating the field of RIBE, it is important to understand the mechanisms and consequences of biological effects as well as the role of exosomes and exosomal miRNAs therein, from different sources and under different circumstances, respectively. More discoveries could help to establish early interventions against RIBE while improving the efficacy of radiotherapy. Meanwhile, measures that would alleviate or even inhibit RIBE to some extent may exist in the near future.
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July 2020
review article|
April 28 2020
Radiation-Induced Bystander Effect can be Transmitted Through Exosomes Using miRNAs as Effector Molecules
Yu Du;
Yu Du
a State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
b Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China
1 These authors contributed equally to this work.
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Shufang Du;
Shufang Du
a State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
d Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China
1 These authors contributed equally to this work.
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Liu Liu;
Liu Liu
a State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
c Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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Feihong Gan;
Feihong Gan
a State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
b Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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Xiaoge Jiang;
Xiaoge Jiang
a State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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Kaijuan Wangrao;
Kaijuan Wangrao
a State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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Ping Lyu;
Ping Lyu
a State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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Ping Gong;
Ping Gong
a State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
b Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China
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Yang Yao
Yang Yao
2
a State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China
b Department of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu, China
1 These authors contributed equally to this work.
2 Address for correspondence: Sichuan University West China College of Stomatology, No. 14, Third Section, Ren Min Nan Road, 610041 Chengdu, China; email: Yaoyang9999@126.com.
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Radiat Res (2020) 194 (1): 89–100.
Article history
Received:
January 07 2020
Accepted:
March 27 2020
Citation
Yu Du, Shufang Du, Liu Liu, Feihong Gan, Xiaoge Jiang, Kaijuan Wangrao, Ping Lyu, Ping Gong, Yang Yao; Radiation-Induced Bystander Effect can be Transmitted Through Exosomes Using miRNAs as Effector Molecules. Radiat Res 8 July 2020; 194 (1): 89–100. doi: https://doi.org/10.1667/RADE-20-00019.1
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