Thyroid doses from intake of radioiodine isotopes (131I, 132Te+132I, and 133I) and associated uncertainties were revised for the 13,204 Ukrainian-American cohort members exposed in childhood and adolescence to fallout from the Chornobyl nuclear power plant accident. The main changes related to the revision of the 131I thyroid activity measured in cohort members, the use of thyroid-mass values specific to the Ukrainian population, and the revision of the 131I ground deposition densities in Ukraine. Uncertainties in doses were assessed considering shared and unshared errors in the parameters of the dosimetry model. Using a Monte-Carlo simulation procedure, 1,000 individual stochastic thyroid doses were calculated for each cohort member. The arithmetic mean of thyroid doses from intake of 131I, 132Te+132I, and 133I for the entire cohort was 0.60 Gy (median = 0.22 Gy). For 9,474 subjects (71.6% of the total), the thyroid doses were less than 0.5 Gy. Thyroid doses for 42 cohort members (0.3% of the total) exceeded 10 Gy while the highest dose was 35 Gy. Intake of 131I contributed around 95% to internal thyroid exposure from radioiodine isotopes. The geometric standard deviation of individual stochastic thyroid doses varied among cohort members from 1.4 to 4.3 with an arithmetic mean of 1.6 and a median of 1.4. It was shown that the contribution of shared errors to the dose uncertainty was small. The revised thyroid doses resulted, in average, in around 40% decrease for cohort members from Zhytomyr Oblast and an increase of around 24% and 35% for the cohort members from Kyiv and Chernihiv Oblast, respectively. Arithmetic mean of TD20 doses for the cohort was around 8% less than that estimated in TD10, 0.60 Gy vs. 0.65 Gy, respectively; however, global median of TD20 doses somewhat increased compared to TD10: 0.22 Gy vs. 0.19 Gy, respectively. The difference between TD10 and TD20 was mainly due to a revision of the individual 131I thyroid activity measured in the cohort members.
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January 2023
RESEARCH ARTICLES|
November 11 2022
Exposure to the Thyroid from Intake of Radioiodine Isotopes after the Chornobyl Accident. Report I: Revised Doses and Associated Uncertainties for the Ukrainian-American Cohort
Sergii Masiuk;
Sergii Masiuk
a State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
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Mykola Chepurny;
Mykola Chepurny
a State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
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Valentyna Buderatska;
Valentyna Buderatska
a State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
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Olga Ivanova;
Olga Ivanova
a State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
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Zulfira Boiko;
Zulfira Boiko
a State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
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Natalia Zhadan;
Natalia Zhadan
a State Institution “National Research Center for Radiation Medicine of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
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Kiyohiko Mabuchi;
Kiyohiko Mabuchi
b Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland
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Elizabeth K Cahoon;
Elizabeth K Cahoon
b Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland
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Mark P Little;
Mark P Little
b Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland
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Alexander Kukush;
Alexander Kukush
c Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
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Tetiana Bogdanova;
Tetiana Bogdanova
d V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
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Victor Shpak;
Victor Shpak
d V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
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Galyna Zamotayeva;
Galyna Zamotayeva
d V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
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Mykola Tronko;
Mykola Tronko
d V.P. Komisarenko Institute of Endocrinology and Metabolism of the National Academy of Medical Sciences of Ukraine, Kyiv, Ukraine
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Vladimir Drozdovitch
Vladimir Drozdovitch
1
b Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, DHHS, Bethesda, Maryland
1 Address for correspondence: 9609 Medical Center Drive, Room 7E548 MSC 9778, Bethesda, MD 20892-9778; e-mail: drozdovv@mail.nih.gov.
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Radiat Res (2023) 199 (1): 61–73.
Article history
Received:
July 15 2022
Accepted:
October 24 2022
Citation
Sergii Masiuk, Mykola Chepurny, Valentyna Buderatska, Olga Ivanova, Zulfira Boiko, Natalia Zhadan, Kiyohiko Mabuchi, Elizabeth K Cahoon, Mark P Little, Alexander Kukush, Tetiana Bogdanova, Victor Shpak, Galyna Zamotayeva, Mykola Tronko, Vladimir Drozdovitch; Exposure to the Thyroid from Intake of Radioiodine Isotopes after the Chornobyl Accident. Report I: Revised Doses and Associated Uncertainties for the Ukrainian-American Cohort. Radiat Res 1 January 2023; 199 (1): 61–73. doi: https://doi.org/10.1667/RADE-21-00152.1
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