Preclinical researchers have long acknowledged the critical need for accurate dosimetry in the conduct of radiation-exposure studies involving living systems. Although radiation dosimetry is required to be National Institute for Standards and Technology (NIST)-traceable for human irradiation protocols, there were previously only limited requirements stipulating accurate radiation exposures for preclinical radiation studies funded by the National Institutes of Health (NIH). In one of the earliest identified publications (1956) that addressed radiation dosimetry in murine studies, Hurst et al. () discussed their calculations surrounding estimating neutron responses, and “distribution of absorbed energy versus LET”. In 2009, Zoetelief et al. () outlined European efforts to harmonize X-ray dosimetry studies in radiation biology, which resulted in the establishment of a protocol to improve dosimetry oversight and allow for better comparison of results across different institutions. It is, however, unclear if these early efforts substantially changed the approach of biologists...

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