The effect of whole-body X-irradiation with an exposure of 1000 R on thyroid function in mice was studied. The rate of thyroid131 I uptake in the irradiated animals was lower than that in the controls on the second day postirradiation. The radiochromatographic study of thyroid tissue hydrolyzates showed gradual suppression of thyroid hormone synthesis after irradiation. The initial 6-hour conversion ratio of plasma131 I was lower in the irradiated animals than in the controls. There was a temporary retardation in the thyroid hormone secretion after irradiation. From these experiments, with the additional support from the previous literature, it was concluded that a whole-body exposure of mice with 1000 R of X-rays acted as a stressor to reduce the various aspects of thyroid function during 6 to 48 hours after the exposure.
Skip Nav Destination
Research Article| March 01 1968
Effect of Whole-Body X-Irradiation on Thyroid Function in the Mouse
Radiat Res (1968) 33 (3): 480–489.
- Views Icon Views
- Share Icon Share
- Search Site
Chang W. Song, Titus C. Evans; Effect of Whole-Body X-Irradiation on Thyroid Function in the Mouse. Radiat Res 1 March 1968; 33 (3): 480–489. doi: https://doi.org/10.2307/3572405
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner