A linear two-compartment open-ended model was used to describe the kinetics of strontium in the rat as a function of age. Strontium-85 was used as the tracer in the eight age groups (39 to 389 days) studied. The numerical solution of the parameters, compartment sizes, and transfer rates was performed by the Berman (NIH-OMR-SAAM) program on an IBM-7094 digital computer. The fit of the experimental data, plasma, urine, feces, and whole-body retention to the model was unique and consistent. The parameters measured, with the exception of the urinary excretion rate, decreased as a function of age in the growing animal. The accretion rate was found to be linearly related to the rate of increase of body weight and to the total exchangeable calcium compartment. This study also demonstrated that the same model could be used, with the same degree of reliability, in man and the rat, which suggests that there is a qualitative similarity in the skeletal dynamics of both animals. The advantage of this digital computer analysis is that it affords a quantitative measure of the accuracy of the calculated parameters as well as objectivity and reproducibility.
Skip Nav Destination
Research Article| March 01 1968
Evaluation of the Parameters of Strontium Metabolism in the Rat as a Function of Age
E. A. Gusmano ;
J. N. Concannon ;
Radiat Res (1968) 33 (3): 540–553.
- Views Icon Views
- Share Icon Share
- Search Site
E. A. Gusmano, J. N. Concannon, S. R. Bozzo, S. H. Cohn; Evaluation of the Parameters of Strontium Metabolism in the Rat as a Function of Age. Radiat Res 1 March 1968; 33 (3): 540–553. doi: https://doi.org/10.2307/3572411
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner
Photon GRID Radiation Therapy: A Physics and Dosimetry White Paper from the Radiosurgery Society (RSS) GRID/LATTICE, Microbeam and FLASH Radiotherapy Working Group
Hualin Zhang, Xiaodong Wu, Xin Zhang, Sha X. Chang, Ali Megooni, Eric D. Donnelly, Mansoor M. Ahmed, Robert J. Griffin, James S. Welsh, Charles B. Simone, II, Nina A. Mayr