In this experiment, the changes in the urinary excretion of taurine were shown in mice irradiated with a dose producing 80% mortality. The greatest increase in taurine occurred on the first day after irradiation. Thereafter taurine content fell rapidly. During the fourth through the ninth day after exposure, the taurine level in the urine remained lower than the normal amount. From the tenth postexposure day, the level again increased markedly. This elevated excretion ran almost parallel with the increase in the daily mortality rate (based on the fraction of the survivors which die during a given day) of irradiated mice. Various doses of taurine were given to mice at various times after irradiation. The therapeutic effect of taurine in the sense of an increase in the fraction of mice surviving for 30 days postexposure was observed when it was given from the second postirradiation day. The effect was pronounced when it was given on the fourth day after irradiation, at which time the amount of taurine in the urine reached its minimum level. It was also demonstrated that the administration of taurine to irradiated mice promotes the recovery of leukocytes.
Skip Nav Destination
Research Article| March 01 1968
Studies on the Significance of Taurine in Radiation Injury
Mitsuyuki Abe ;
Masaji Takahashi ;
Katsumi Takeuchi ;
Radiat Res (1968) 33 (3): 563–573.
- Views Icon Views
- Share Icon Share
- Search Site
Mitsuyuki Abe, Masaji Takahashi, Katsumi Takeuchi, Masasi Fukuda; Studies on the Significance of Taurine in Radiation Injury. Radiat Res 1 March 1968; 33 (3): 563–573. doi: https://doi.org/10.2307/3572413
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner
Photon GRID Radiation Therapy: A Physics and Dosimetry White Paper from the Radiosurgery Society (RSS) GRID/LATTICE, Microbeam and FLASH Radiotherapy Working Group
Hualin Zhang, Xiaodong Wu, Xin Zhang, Sha X. Chang, Ali Megooni, Eric D. Donnelly, Mansoor M. Ahmed, Robert J. Griffin, James S. Welsh, Charles B. Simone, II, Nina A. Mayr