Immunoelectrophoretic analyses were made on sera of C3H mice after steady-state whole-body exposures to <tex-math>${\rm LD}_{20(30)}$</tex-math> or <tex-math>${\rm LD}_{80(30)}$</tex-math> doses of monoenergetic 14-MeV neutrons or mixed gamma-neutron radiations. Marked differences were seen in the <tex-math>$\beta _{2}\text{-globulin}$</tex-math> response of the animals to the two sources during the first week postirradiation as tested by immunoelectrophoresis in agar gel. Monoenergetic 14-MeV neutron radiation at all doses resulted in augmentation of a <tex-math>$\beta _{2}\text{-globulin}$</tex-math> such that the precipitin line extended into the α-region. This qualitative increase was clearly evident by the third postirradiation day and appeared to be at its maximum by the fifth day. In the LD20 groups, there were signs of return to normal on the sixth and seventh days, but the increased component persisted throughout the experimental period in the <tex-math>${\rm LD}_{80}$</tex-math> animals. By contrast, the mixed gamma-neutron radiations produced little change in this <tex-math>$\beta _{2}\text{-globulin}$</tex-math> and that only after 5 days at the higher dose level. Specific staining of the immunoelectrophoretic patterns revealed the affected globulin to be a glycoprotein.

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