Sixteen Macaca mulatta monkeys were exposed to a single 2500-R dose of cobalt-60 gamma irradiation at a dose rate of 500 R/min. Immediately following irradiation there was precipitous decline in cerebral blood flow. The initial decline was followed by a period of partial recovery within 20 to 30 minutes, with a subsequent slower secondary decrease in cerebral blood flow thereafter. Alterations in cerebral blood flow were accompanied by parallel changes in systemic blood pressure. Following irradiation there was a phase of immediate hypotension followed by transient partial recovery at 20 to 30 minutes. Contributing to the observed decrease in cerebral blood flow following irradiation was an apparent impairment of the normal regulatory function of the cerebral vasculature in maintaining adequate blood flow. The cerebral blood flow decline was of a degree that might be expected to produce impairment of normal CNS function. It occurred at a time during which behavioral incapacitation has been observed following supralethal doses of ionizing radiation, suggesting a causal relationship.
Skip Nav Destination
Research Article| July 01 1968
Effect of Cobalt-60 Gamma Irradiation on Blood Pressure and Cerebral Blood Flow in the Macaca mulatta
Radiat Res (1968) 35 (1): 78–85.
- Views Icon Views
- Share Icon Share
- Search Site
Paul H. Chapman, Robert J. Young; Effect of Cobalt-60 Gamma Irradiation on Blood Pressure and Cerebral Blood Flow in the Macaca mulatta. Radiat Res 1 July 1968; 35 (1): 78–85. doi: https://doi.org/10.2307/3572435
Download citation file:
Citing articles via
Commonalities Between COVID-19 and Radiation Injury
Carmen I. Rios, David R. Cassatt, Brynn A. Hollingsworth, Merriline M. Satyamitra, Yeabsera S. Tadesse, Lanyn P. Taliaferro, Thomas A. Winters, Andrea L. DiCarlo
Monte Carlo Simulation of SARS-CoV-2 Radiation-Induced Inactivation for Vaccine Development
Ziad Francis, Sebastien Incerti, Sara A. Zein, Nathanael Lampe, Carlos A. Guzman, Marco Durante
Low-Dose Radiation Therapy (LDRT) for COVID-19: Benefits or Risks?
Pataje G. Prasanna, Gayle E. Woloschak, Andrea L. DiCarlo, Jeffrey C. Buchsbaum, Dörthe Schaue, Arnab Chakravarti, Francis A. Cucinotta, Silvia C. Formenti, Chandan Guha, Dale J. Hu, Mohammad K. Khan, David G. Kirsch, Sunil Krishnan, Wolfgang W. Leitner, Brian Marples, William McBride, Minesh P. Mehta, Shahin Rafii, Elad Sharon, Julie M. Sullivan, Ralph R. Weichselbaum, Mansoor M. Ahmed, Bhadrasain Vikram, C. Norman Coleman, Kathryn D. Held
Germicidal Efficacy and Mammalian Skin Safety of 222-nm UV Light
Manuela Buonanno, Brian Ponnaiya, David Welch, Milda Stanislauskas, Gerhard Randers-Pehrson, Lubomir Smilenov, Franklin D. Lowy, David M. Owens, David J. Brenner
RITCARD: Radiation-Induced Tracks, Chromosome Aberrations, Repair and Damage
Ianik Plante, Artem Ponomarev, Zarana Patel, Tony Slaba, Megumi Hada