Changes in the fine structure of the thyroid follicular epithelium at selected times during the first week after midlethal irradiation of young dogs were similar to those seen after the administration of thyroid stimulating hormone. This similarity supports the observations of others that the early thyroid response is mediated by increased pituitary activity. The hypertrophy and edema of the endothelial cells of small blood vessels soon after irradiation and the subsequent endothelial atrophy seen later were consistent with the hemorrhagic diathesis which undoubtedly would have developed in these dogs.

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