The radiation LD50 response at 30 days and at 90 days was determined for (C57BL/Cum ♀ × C3H/Anf Cum ♂ F1 mice receiving syngeneic marrow doses from 5× 104 to 2× 108 nucleated cells. A biphasic response proportional to the logarithm of the cell dose was obtained, with the break coming at about 2× 105 cells. The results suggest an optimum cell dose of 2 to 5× 106 nucleated cells to obtain recovery from supralethal radiation doses.
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Research Article| February 01 1969
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David G. Doherty; Effect of Syngeneic Bone Marrow Cell Dose on the 30-Day and 90-Day LD50 of X-Irradiated Mice. Radiat Res 1 February 1969; 37 (2): 299–304. doi: https://doi.org/10.2307/3572733
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