The radiation LD50 response at 30 days and at 90 days was determined for (C57BL/Cum ♀ × C3H/Anf Cum ♂ F1 mice receiving syngeneic marrow doses from 5× 104 to 2× 108 nucleated cells. A biphasic response proportional to the logarithm of the cell dose was obtained, with the break coming at about 2× 105 cells. The results suggest an optimum cell dose of 2 to 5× 106 nucleated cells to obtain recovery from supralethal radiation doses.

This content is only available as a PDF.
You do not currently have access to this content.