Nitric oxide gas, like oxygen, sensitizes biological material to ionizing radiation. Also, like oxygen, the nitric oxide is used up during irradiation. Thus, when the total dose is delivered in 2 microseconds, the annitricoxic radiosensitivity is observed for part of the dose. Unlike oxygen, there is a post-nitric oxide treatment effect at both low and high dose rates. Also, unlike oxygen, high concentrations of nitric oxide fail to sensitize at low dose rates, but do sensitize at high dose rates.

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