The radiation response of cultured Chinese Hamster ovary cells was found to be increased during a period of decreased respiratory activity caused by the addition of glucose (Crabtree effect). This increased sensitivity was demonstrated as both a decreased rate of growth in suspension culture and a reduction in colony-forming ability, as compared to cells irradiated in normal growth medium. These results may be accounted for by increase in intracellular oxygen tension and decreases in NADH plus NADPH during radiation.
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Research Article| September 01 1969
Modification of Radiation Response through Glucose-Controlled Respiration
John E. Biaglow ;
Paul S. Lavik ;
Radiat Res (1969) 39 (3): 623–633.
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John E. Biaglow, Paul S. Lavik, Nicholas Ferencz,; Modification of Radiation Response through Glucose-Controlled Respiration. Radiat Res 1 September 1969; 39 (3): 623–633. doi: https://doi.org/10.2307/3572941
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