The radiation response of cultured Chinese Hamster ovary cells was found to be increased during a period of decreased respiratory activity caused by the addition of glucose (Crabtree effect). This increased sensitivity was demonstrated as both a decreased rate of growth in suspension culture and a reduction in colony-forming ability, as compared to cells irradiated in normal growth medium. These results may be accounted for by increase in intracellular oxygen tension and decreases in NADH plus NADPH during radiation.

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